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Mobilization of plasmacytoid and myeloid dendritic cells to mucosal sites in children with respiratory syncytial virus and other viral respiratory infections. Human respiratory syncytial virus RSV causes bronchiolitis in infants and young children as well as severe respiratory illness in the elderly and immunocompromised adults 12. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Virology Antiviral Res.

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    Sang-Moo Kang, professor at Georgia State University, is focused on research to design and develop effective vaccines against viral diseases.

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    Sang-Moo Kang, professor in the Institute for Biomedical Sciences at Georgia State University, has renewed a four-year, $ Sang-Moo Kang of Georgia State University, GA (GSU) | Read publications | Contact Sang-Moo Kang.
    Cellular immune correlates preventing disease against respiratory syncytial virus by virus-like particle vaccine.

    VLP vaccines proposed in this application will provide an excellent system to prove VLP vaccine technologies which are also applicable to other biodefense pathogens. Delayed sequelae of neonatal respiratory syncytial virus infection are dependent on cells of the innate immune system. Viruslike particle vaccine induces protection against respiratory syncytial virus infection in mice.

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    Figure 4. Wohlbold TJ, Krammer F.

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    Intracellular Cytokine Staining and Flow Cytometry Assay For intracellular cytokine analysis, harvested cells were stimulated with M2e peptides and then stained with fluorescence-labeled anti-mouse CD4 and anti-mouse CD8 antibodies.

    For intracellular cytokine analysis, harvested cells were stimulated with M2e peptides and then stained with fluorescence-labeled anti-mouse CD4 and anti-mouse CD8 antibodies. In our preliminary studies, we rescued recombinant influenza viruses expressing a chimeric HA molecule with conserved M2e epitopes 4xM2e-HA, M2e-HA using reverse genetics.

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    Conflicts of Interest: The authors declare no potential conflicts of interest. Recent in Grantomics:. Respiratory syncytial virus infection in elderly and high-risk adults. Virus-like particle vaccines containing F or F and G proteins confer protection against respiratory syncytial virus without pulmonary inflammation in cotton rats.

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    Influenza vaccines inducing broadly cross protective immunity SangMoo Kang

    Sang-Moo has 1 job listed on their profile. See the complete profile on. Dr. Sang-Moo Kang, professor in the Institute for Biomedical Sciences at Georgia State University.

    SangMoo Kang – The Conversation

    This is Dr. Sang-Moo Kang, professor in the Institute for Biomedical Sciences at Georgia State University.
    Virus-like particle vaccines containing F or F and G proteins confer protection against respiratory syncytial virus without pulmonary inflammation in cotton rats.

    Vaccine 27 32 —4. Additionally, extensive monocytes can contribute to immunopathology and degenerative disease Supplementary Materials.

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    Monocyte recruitment during infection and inflammation. Immunology ;—

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    Sang moo kang georgia state university
    Protective immunity against H5N1 influenza virus by a single dose vaccination with virus-like particles.

    VLP Vaccine Technology SangMoo Kang

    Aim 2 will investigate the contribution of cellular and humoral immune mechanisms to cross protection by recombinant influenza virus vaccines using wild type and mutant mouse models. Trends Immunol Overall, the results of lung viral titers show a correlation with protection as indicated by weight loss.

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    Published online May Roles of major histocompatibility complex class II in inducing protective immune responses to influenza vaccination.

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    1. Immunization with low doses of recombinant postfusion or prefusion respiratory syncytial virus F primes for vaccine-enhanced disease in the cotton rat model independently of the presence of a Th1-biasing GLA-SE or Th2-biasing alum adjuvant. Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies.

    2. Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus. Cellular immune correlates preventing disease against respiratory syncytial virus by virus-like particle vaccine.